Natural Cycle FET; a lower intervention technique for Frozen Embryo Transfer

In the field of reproductive medicine, we are always seeking new and improved ways to create successful pregnancies. One technique that has gained a lot of attention recently is Natural Cycle FET. This protocol involves basing the timing of an embryo transfer off or a woman’s natural cycle with minimal medical interventions. As we gather more data on success rates using this technique we will be able to better decide which patients are most likely to become pregnant on this protocol.  Here is a link to an episode of our Clinical Conversation series where we are trying to create a balanced discussion of the potential pros and cons of Natural Cycle FET.  Most noteworthy, we are currently finding about 20% of cycles have to be cancelled as the parameters developing do not seem ideal for the support of implantation.

Natural Cycle FET: clinical conversations with Dr. Greene and fertility coach Lisa White

(~14 minutes):

0:35 Definition: what is Natural Cycle FET?  

3:00 Comparing fertility and implantation

3:40 Current recommendations of patients best suited for Natural FET

4:45 Possible advantages of Natural Cycle FET

5:10 Possible disadvantages of Natural Cycle FET

6:00 Submitted question: How does the Endometrial Receptivity Analysis fit in with Natural Cycle FET?   

6:40 Convention or “Programmed Cycle”  

7:30 Optimizing timing and potential differences from one fertility center to another

11:00 Individualizing treatment plans. It’s good to have options.

12:30 Supporting informed decision-making as we gather more data

As we gather more data and experience with Natural Cycle FET we will become better qualified to guide patients more actively. Until then, my goal is to partner with each patient/couple to make these decisions together.

With stubborn optimism,


Robert Greene, MD, FACOG

Conceptions Reproductive Associates of Colorado

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