Common chemicals in shaving cream and soaps tied to poor semen quality

shave

Men are often unaware of how their personal care products may be limiting their fertility potential. Several studies have focused in on a common ingredient called parabens. This is a commonly used preservative in shaving creams, soaps and cosmetics–and is known by a variety of names including “methyl-parabens and propyl-parabens.”

Another study has now found that this chemical can not only disrupt healthy hormone levels but actually contribute to potential sperm damage. Specifically, they found a higher incidence of sperm with abnormal shapes (called teratospermia”) as well as a higher incidence of sperm DNA damage.

Since shaving involves scraping the skin–this daily activity provides a very unhealthy opportunity to absorb this hormone-disruptor. So consider switching to products that are “parabens-free” or certified organic.

Coffee, Tea and Fertility: time to re-evaluate an outdated concept

Coffee

As both a physician and researcher, I have come to realize that it is much more difficult to dispel a popular belief that is wrong than it is to prove a new finding. A classic example is the popular notion that coffee and tea are harmful for women trying to conceive. Both are drinks created from small trees/shrubs—coffee is made from the seed (not bean) of the plant Cofea Arabica whereas tea is made from the leaves of the plant Camellia sinensis. Interesting, both are now known to have a growing number of health benefits. In fact, both—when served unsweetened—regularly appear after water as the “second healthiest beverage” to consume in moderate quantities of 3 to 4 cups per day.

Both coffee and tea contain various plant produced antioxidants as well as health promoting polyphenols and flavonoids. Coffee has been shown to reduce the risk of diabetes and tea is linked to a reduced risk of heart disease. Both are linked to a longer life expectancy. In fact, in 2016 the Nurses Health Study demonstrated that moderate coffee consumption may even protect DNA—potentially slowing the effects of aging and possibly even optimizing fertility. So where does the negative reputation of these beverages come from? I link this myth to obsolete observational studies and the concerns that they raised about caffeine consumption.

Here’s what the current information shows:

 

Bottom line is that these low calorie, plant based beverages may have some health and fertility boosting benefits. Any risk from them is not associated with mild to moderate daily consumption.

Stay informed,

~Robert

Robert Greene, MD, FACOG

Conceptions Reproductive Associates of Colorado

Metformin and Fertility Treatment: the expanding uses for an age-old drug

We all get excited about new things. But most people remain skeptical when you suggest that something old may be better. In fact, what if something VERY old may be one of the hottest developments in a high tech field like fertility treatment? That’s what has been quietly happening with the medication known as metformin.

Galego officianalis

Metformin has been used since the time of the pharaohs (around 1500 B.C.E.) but it was extracted from the plant Galega officinalis (see image). From then until the discovery of insulin; this was the primary treatment for diabetes. Unfortunately, like many plant extracts there were many other compounds present as well—some with serious and/or troubling side effects. The modern synthesized version of metformin has been purified making it safer and easier to study.

 

The best known use of metformin in reproductive medicine is in the treatment of women with polycystic ovarian syndrome (PCOS). But we’re now learning that there are many other ways that his modern version of an herbal remedy can help improve the outcome of fertility treatment. Although I’m not a fan of lists, the complexity of this treatment is beyond a simple blog post. So here is what you may want to consider when planning your treatment with your doctor:

 

 

In summary, pregnancy is a very multifaceted process. Sometimes, we still have a lot to learn about something that has been around for a long time.

Joyfully Assisting the LGBT Community in achieving their reproductive goals

Pride 2017

As Denver celebrates Pride Week; we wanted to reach out and extend our gratitude to our LGBT patients for accepting our invitation to help them create the family of their dreams. We realize that you haven’t always received compassionate care from the medical community and that you—like everyone else—want building your family to be as exciting and as efficient as possible. In fact, some of you have traveled to us from other states and even across oceans seeking such a setting. We’re proud that you chose us. Here’s to all of you!

In deepest gratitude,

The TEAM at Conceptions Reproductive Associates of Colorado

Atypical PCOS: new insights for patients with fertility problems that don’t have other symptoms

Women with Polycystic Ovarian Syndrome (PCOS) can have a variety of symptoms including irregular/infrequent menstrual cycles, skin problems and weight gain. This creates a diagnostic challenge as many healthcare providers rely heavily upon these symptoms to make their diagnosis. New discoveries over the last two decades have demonstrated that PCOS is not a simple cluster of findings.  Instead it is a spectrum of conditions with a variety of presentations. New information has provided greater understanding why some PCOS patients may present primarily with infertility alone and none of the other commonly associated symptoms.

 

PCOS is essentially a hormone imbalance. One of the most important hormones that is typically involved is one called Anti-Müllerian Hormone (AMH). What’s disappointing is that some physicians either don’t measure this hormone or don’t understand its implications. Many women with PCOS have very high levels of AMH. Having too much of this hormone may be their greatest obstacle to becoming pregnant.

 

A new study shows that AMH (referred to as Müllerian Inhibiting Substance or MIS in this article) can inhibit the maturation of eggs. In fact, it can be so potent that it may someday be used as a contraceptive. But most importantly, having a high AMH level can make a woman’s ovaries behave like a woman that has PCOS; even if she does not have any of the other common symptoms. Regardless of what we call this hormone imbalance; women with a high AMH often benefit from similar treatment recommendations as women with PCOS.

 

Stay informed,

~Robert

 

Robert Greene, MD, FACOG

Conceptions Reproductive Associates of Colorado

Egg Quality: new insights into why human eggs don’t age well

It has long been accepted that the primary reason that human eggs don’t age well is due to a dysfunction in when and how the chromosomes separate. This reduced chance of becoming pregnant associated with aging as well as the increased miscarriage rates. A new paper has now demonstrated that it’s not just the DNA separation that declines with time but also how the chromosomes are actually sorted and divided.

Within each egg are cable-like structures called microtubules. These microtubules not only help the egg maintain its shape but also are integral in sorting/separating the DNA. They are also in charge of cell division after fertilization is complete. In fact, some of the most powerful cancer fighting drugs are used to deliberately damage microtubules in order to prevent cancers from growing. This new information provides us with further insight into another important aspect of egg quality.

Although we don’t currently have any specific recommendations on what we can do to improve microtubule function; this information does provide us with more diagnostic information for patients that are going through In Vitro Fertilization (IVF). IVF is not only the treatment that provides patients with the highest pregnancy rates but when performed in a high quality setting; it also provides important diagnostic information. There is no accurate test for egg quality except to put a healthy sperm inside and see if/how well the process of fertilization and development takes place. We routinely use this information in discussing treatment options for patients that do not successfully conceive in their first IVF cycle at our center.

Fertile thoughts,

~Robert

Robert Greene, MD, FACOG

Conceptions Reproductive Associates

Thyroid Hormone for Women Trying to Conceive; why extracts and T3 can be harmful to your developing baby

Many patients that present to fertility centers are on thyroid supplements that are extracts from pig thyroid gland. Unfortunately, they have often embraced this treatment because it is presented as more “natural” then  the synthetic thyroxine often prescribed by most healthcare providers. In reality, the human thyroid gland converts T4 (thyroxine) into T3 (the active form) very efficiently. The typical ratio of T4:T3 in humans is about 14:1. By contrast, pig thyroid extracts have a 4:1 ratio so that there is much more active T3 in the preparation. The problem with this high level of T3 is that the developing baby needs the T4 from a pregnant mom’s blood; not T3. High T3 levels during early pregnancy can impair healthy brain development. So I recommend the following: 

          –take a stable dose of thyroxine. 

          –If you still feel challenged; consider meeting with an endocrinologist to see if you might be a candidate for small supplemental dose of T3; two or three times per day. 

http://endocrinenews.endocrine.org/controversy-continues-combination-treatment-hypothyroidism/