Egg and embryo freezing/banking have become extremely popular options over the last year. A major factor in this decision is Long Term Storage. Eggs and embryos can safely remain frozen for years until you are ready to use them. It is important to feel confident that your samples are stored at a reputable establishment in a safe, transparent, and accessible location. The TMRW tank is an evolution from our current equipment. The basic foundation is not brand new, since we have used cryotanks safely for years, but the software integration system is state of the art. It paves the way for a future where gamete and embryo data can be tracked remotely from our computers, or an app on your phone. Better still you have the assurance that your eggs and embryos are being monitored 24 hours a day every day of the year. Below is a summary of the TMRW Tank concept!
What is it?
TMRW Tank is the first and only automated egg/embryo storage platform
It links frozen egg/embryos to traceable RFID chips to completely prevent errors of identification
It facilitates labeling, tracking & locating samples
It gathers data to ensure cryogenic temperatures & egg/embryo wellness
It integrates all data into a software system monitored on our computers
It replaces old-fashioned liquid nitrogen storage tanks and manual labeling/monitoring
Why is it necessary?
Safer and more secure identification system- 100% digital chain of custody tracking
Easier monitoring in real-time with integrated software system on computer
Integrates embryology storage with the most up-to-date software technology
Who is using it?
The TMRW tank was rolled out to 30 leading fertility clinics in the US, including Conceptions
It was created by TMRW Life Sciences
When/where will it be in use?
Commercial launch was in December of 2020
The TMRW Tank is already at Conceptions Reproductive Associates of Colorado!
Birth rates now are about half of what they were during the height of the “baby boom.” That’s because women are waiting to start their family until they are more settled in their careers, relationships and lifestyles. Unfortunately, this same study also found that about 40% of women between 44 and 50 years of age have had fewer children then they would have preferred. That’s why it is so important that women consider what their family buildings are and consider egg freezing during their mid thirties. Technology now offers women the best of both worlds; delayed reproduction and achieving their ideal family size! https://www.washingtonpost.com/news/wonk/wp/2016/08/16/why-american-women-are-having-fewer-babies-than-ever/
You were born with every egg that you’ll ever have. Although studies suggest that there may be a process where we can create eggs; such technology is far into the future. More importantly, you’re losing eggs at a rate that far exceeds what you would guess. Current research suggests that most women will lose about 500 to 1000 eggs per month through a process of attrition called apoptosis—yet only one or two eggs each month will be capable of fertilization. A recent summary of all of the available research has shown that most women will only have about 3% of their eggs remaining by age 40.
Although the slope of that curve appears intimidating, the goal of this blog post is to increase your awareness and to empower you to take action. Some women are born with more eggs than others. Some women will lose their eggs at a faster rate. Most importantly, the eggs that remain in your ovaries at any given moment represent your ovarian reserve. Therefore, it is very relevant for you to consider how many eggs you have now and then plan how many (more) children you think you might someday wish to have.
This diagram shows the various stages of egg development summarized in a single ovary.
It takes an egg several months to develop from its status as a primordial follicle to that of a mature fertilizable oocyte. It is only when they reach that stage that the ovary releases the egg through a process called ovulation. Fewer than 300 of your eggs are likely to ever complete this journey. In other posts on this blog, we focus on various steps you can take to optimize the health of your developing eggs; but for now let’s focus on the future of your fertility in the months and years to come.
At least 99% of your remaining eggs are dormant—alive but not metabolically active. They have been in this resting state since you were a newborn. The eggs that are in these intermediate stages of development—which represents your fertility—can be estimated by a simple well timed blood test. Consider having your ovarian reserve tested today. Then think about how many children you envision yourself having. Consider when you will be ready to start or expand your family. By doing so, you can better estimate whether or not egg freezing or embryo banking (creating and storing embryos for future use) are steps you should be considering to assist you in creating your future family.
One of the most frustrating questions for women trying to conceive is “what can I do to improve my chances?” Given that women are born with every egg that they will ever have, there are a limited number of ways to optimize the health of the remaining eggs. But for those that are motivated, I have described steps like the use of Acai berry extract and CoQ10 as well as improved sleep and Vitamin D. Now for the first time, there is evidence that some women may be able to improve the responsiveness of their ovaries in as little as one month!
The typical diet of people living in the USA has changed dramatically over the last century. One glaring example has been in the type of fats that we consume on a daily basis. Essential dietary fats—those that we must get from foods because our bodies can’t make them—are typically classified as Omega-6 and as Omega-3 and serve many important physiologic functions. The ideal ratio of Omega-6 to Omega-3 is 1-to-1. However, the typical Western diet—popular amongst most Americans—has a ratio as high as 25-to-1. The result of this unhealthy shift is that many people are eating foods that promote inflammation. This unhealthy shift is associated with a higher risk of heart disease, diabetes, cancer and infertility.
Given that it’s not easy to encourage people to make lasting dietary changes, a recent study looked at the effects of starting a high potency omega-3 fatty acid supplement upon ovarian function and hormone balance. For this study, they put 27 women on a 4 gram supplement and measured their FSH levels before and 30 days after starting this program. Even within this short time frame—effectively one menstrual cycle—they found a dramatic improvement in the omega-6 to omega-3 ratio. Their inflammatory markers improved and their FSH levels dropped. Given that FSH level is considered a marker of ovarian sensitivity; this result is interpreted to mean that their ovaries were more sensitive and thus more fertile.
A cautionary note; they did not find an improved ovarian sensitivity in the women in the study that were obese. It is possible that with longer time and with weight loss, obese women might also experience improved fertility. Obesity has been linked to worsening infertility as well as resistance to some of the treatments offered to normal weight women. It is theorized that obesity itself produces inflammatory chemicals in the body which in turn trigger a state of hormone imbalance. In act, it was discovered that all of the women in the study—including the women that were obese—had improved markers of glucose metabolism. That suggests that the omega-3 fatty acids could help reduce the risk of diabetes and maybe make it easier to lose weight as well.
Another important benefit of omega-3 fatty acids is that they can reduce oxidative stress. That means that consuming these healthy dietary fats can reduce the risk of DNA damage to a woman’s eggs—another important fertility promoting benefit. So although this was a small study and needs to be confirmed in a longer time period, you don’t need to wait. Make this health promoting change in your fertility promoting plan now. Here are a few practical suggestions:
Switch to a low-fat diet plan taking care to avoid animal fats when possible
Use products at home that include healthy omega-3 fatty acids instead of butter
Incorporate more olive oil, Flax seeds and tree nuts into your daily diet
Start taking a daily supplement—preferably a plant based one (rather than fish oil) like those made by Life’s DHA
IMPORTANT NOTE TO MEN: Emerging evidence suggests that increasing your omega-3 fatty acid consumption can improve sperm shape (teratospermia) as well!!
Within days of writing about the modern benefits of egg freezing a new study was published in JAMA based upon old data. They looked at national data from 2013 and concluded that pregnancy rates from egg donors were lower if the eggs had been frozen than if they were fresh. That was probably true back then. But technology is advancing at an exponential rate. Reproductive medicine is arguably one of the most technology dependent fields of medicine. So applying 2013 results to current decision making is flawed from the very onset. Having said that, let’s consider what this publication may be able to teach us and how we should more accurately interpret it today.
This study looked at the 2013 Annual Report of the pregnancy rates from fertility centers in the USA which were collected by the Society for Assisted Reproductive Technology. The science and experience of most centers using this technology has advanced considerably since then. In fact, it was in late 2013 that the Practice Committee for the American Society for Reproductive Medicine published the guidelines for oocyte cryopreservation. In their review they pointed out the fact that much of the data that they analyzed was from Europe as few clinics in the USA had published their experience with egg freezing at that time. They also clarified how the difference in techniques used to freeze/thaw the eggs had progressed rapidly resulting in dramatic improvements in success rates. As a result, the removed the “experimental label” from the procedure because of these advances. However one of their most important ultimate conclusions was that “success rates may not be generalizable, and clinic-specific success rates should be used to counsel patients whenever possible.” Despite that clearly stated recommendation, this latest research paper lumped together all of the clinic data and created the latest public misinformation campaign.
Today, many more centers have experience in freezing/thawing eggs using the most modern technique of vitrification. As a result, more patients that need donor eggs are able to benefit from the lower cost and greater convenience of frozen eggs and still enjoy the very best in success rates. Better still, many egg banks offer special guarantees so that if a specific donor’s eggs do not perform well: they will have access to replacement eggs without additional cost. So the best message for patients in need of donor eggs today is to be a wise consumer. Patients should ask their clinical very candidly about their unique experience with frozen donor eggs. I think that they will find greater reassurance in today’s science than in yesterday’s news.